Ku80

X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
	PDB rendering based on 1jeq.
Доступные структуры
PDB	Поиск ортологов: PDBe, RCSB
	Список идентификаторов PDB 1JEQ, 1JEY, 1Q2Z, 1RW2, 3RZ9
Идентификаторы
Символ	XRCC5 ; KARP-1; KARP1; KU80; KUB2; Ku86; NFIV
Внешние ID	OMIM: 194364 MGI: 104517 HomoloGene: 40681 GeneCards: Ген XRCC5
номер EC	3.6.1. EC 3.6.1.
Функция	• DNA binding; • damaged DNA binding; • double-stranded DNA binding; • double-stranded telomeric DNA binding; • ATP-dependent DNA helicase activity; • protein binding; • ATP binding; • protein C-terminus binding; • ubiquitin protein ligase binding; • telomeric DNA binding; • transcription regulatory region DNA binding; • poly(A) RNA binding; • 5'-deoxyribose-5-phosphate lyase activity;
Компонент клетки	• nuclear telomere cap complex; • nuclear chromosome, telomeric region; • nucleus; • nucleoplasm; • nucleolus; • cytosol; • plasma membrane; • membrane; • Ku70:Ku80 complex; • nonhomologous end joining complex;
Биологический процесс	• telomere maintenance; • DNA repair; • double-strand break repair; • double-strand break repair via nonhomologous end joining; • DNA recombination; • transcription, DNA-templated; • cell proliferation; • viral process; • positive regulation of type I interferon production; • DNA duplex unwinding; • innate immune response; • negative regulation of transcription, DNA-templated; • regulation of smooth muscle cell proliferation; • positive regulation of neurogenesis; • hematopoietic stem cell differentiation; • establishment of integrated proviral latency;
	Источники: Amigo / QuickGO
Профиль экспрессии РНК
	Больше информации
Ортологи

Ku80 — белок, закодированный у человека геном XRCC5.^[1] Вместе с белком Ku70 белок Ku80 образует гетеродимер, связывающийся с концами двунитевых разрывов в ДНК, и требуется для репарации ДНК путём негомологичного соединения концов (NHEJ). Также белок Ku требуется для V(D)J рекомбинации, которая использует путь NHEJ для создания разнообразия антиген-связывающих центров антител в иммунной системе млекопитающих.

Также Ku требуется для поддержания длины теломер и сайленсинга прителомерных генов.^[2]

Ku был впервые обнаружен у пациентов с системной красной волчанкой, у которых были выявлены высокие титры антител против этого белка.^[1]

Ku80 имеет несколько других названий:

Ku аутоантиген, белок p80 волчанки
субъединица 2 АТР-зависимой ДНК-хеликазы 2
XRCC5 (англ. X-ray repair cross-complementing 5)

Клиническое значение

Редкий микросателлитный полиморфизм данного гена связан с опухолями у пациентов с различной чувствительностью к радиоактивности.^[3]

Взаимодействия

Показаны белок-белковые взаимодействия Ku80 с NCOA6,^[4]^[5] GCN5L2,^[6] Ku70,^[6]^[7]^[8]^[9]^[10] АТР-зависимой хеликазой синдрома Вернера,^[11]^[12] Тирозин-киназой 2,^[13] белком c-Abl в гомологичном киназе каталитическом участке ДНК-зависимой протеинкиназы,^[14]^[15]^[7] TERF2IP,^[16] обратной транскриптазой теломер,^[17] POU2F1^[18]^[15] и белком PCNA.^[15]^[19]^[20]

Примечания

↑ ¹ ² Entrez Gene: XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa) .
↑ Boulton S.J., Jackson S.P. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing (англ.) // EMBO J. : journal. — 1998. — March (vol. 17, no. 6). — P. 1819—1828. — doi:10.1093/emboj/17.6.1819. — PMID 9501103. — PMC 1170529.
↑ Entrez Gene: XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa) . Архивировано 8 марта 2010 года.
↑ Ko, L; Cardona G R., Chin W W. Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — UNITED STATES, 2000. — May (vol. 97, no. 11). — P. 6212—6217. — ISSN 0027-8424. — PMID 10823961.
↑ Ko, Lan; Chin William W. Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase (англ.) // J. Biol. Chem. : journal. — United States, 2003. — March (vol. 278, no. 13). — P. 11471—11479. — ISSN 0021-9258. — doi:10.1074/jbc.M209723200. — PMID 12519782.
↑ ¹ ² Barlev, N A; Poltoratsky V., Owen-Hughes T., Ying C., Liu L., Workman J L., Berger S L. Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex (англ.) // Mol. Cell. Biol. : journal. — UNITED STATES, 1998. — March (vol. 18, no. 3). — P. 1349—1358. — ISSN 0270-7306. — PMID 9488450.
↑ ¹ ² Gell, D; Jackson S P. Mapping of protein-protein interactions within the DNA-dependent protein kinase complex (англ.) // Nucleic Acids Res. : journal. — ENGLAND, 1999. — September (vol. 27, no. 17). — P. 3494—3502. — PMID 10446239.
↑ Yang, C R; Yeh S., Leskov K., Odegaard E., Hsu H L., Chang C., Kinsella T J., Chen D J., Boothman D A. Isolation of Ku70-binding proteins (KUBs) (англ.) // Nucleic Acids Res. : journal. — ENGLAND, 1999. — May (vol. 27, no. 10). — P. 2165—2174. — ISSN 0305-1048. — PMID 10219089.
↑ Singleton, B K; Torres-Arzayus M I., Rottinghaus S T., Taccioli G E., Jeggo P A. The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit (англ.) // Mol. Cell. Biol. : journal. — UNITED STATES, 1999. — May (vol. 19, no. 5). — P. 3267—3277. — ISSN 0270-7306. — PMID 10207052.
↑ Song, K; Jung D., Jung Y., Lee S G., Lee I. Interaction of human Ku70 with TRF2 (англ.) // FEBS Lett. : journal. — NETHERLANDS, 2000. — September (vol. 481, no. 1). — P. 81—5. — ISSN 0014-5793. — PMID 10984620.
↑ Karmakar, Parimal; Snowden Carey M., Ramsden Dale A., Bohr Vilhelm A. Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus (англ.) // Nucleic Acids Res. : journal. — England, 2002. — August (vol. 30, no. 16). — P. 3583—3591. — PMID 12177300.
↑ Li, B; Comai L. Functional interaction between Ku and the werner syndrome protein in DNA end processing (англ.) // J. Biol. Chem. : journal. — UNITED STATES, 2000. — September (vol. 275, no. 37). — P. 28349—28352. — ISSN 0021-9258. — doi:10.1074/jbc.C000289200. — PMID 10880505.
↑ Adam, L; Bandyopadhyay D., Kumar R. Interferon-alpha signaling promotes nucleus-to-cytoplasmic redistribution of p95Vav, and formation of a multisubunit complex involving Vav, Ku80, and Tyk2 (англ.) // Biochem. Biophys. Res. Commun. : journal. — UNITED STATES, 2000. — January (vol. 267, no. 3). — P. 692—696. — ISSN 0006-291X. — doi:10.1006/bbrc.1999.1978. — PMID 10673353.
↑ Jin, S; Kharbanda S., Mayer B., Kufe D., Weaver D T. Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit (англ.) // J. Biol. Chem. : journal. — UNITED STATES, 1997. — October (vol. 272, no. 40). — P. 24763—24766. — ISSN 0021-9258. — PMID 9312071.
↑ ¹ ² ³ Matheos, Diamanto; Ruiz Marcia T., Price Gerald B., Zannis-Hadjopoulos Maria. Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication (англ.) // Biochim. Biophys. Acta : journal. — Netherlands, 2002. — October (vol. 1578, no. 1—3). — P. 59—72. — ISSN 0006-3002. — PMID 12393188.
↑ O'Connor, Matthew S; Safari Amin, Liu Dan, Qin Jun, Songyang Zhou. The human Rap1 protein complex and modulation of telomere length (англ.) // J. Biol. Chem. : journal. — United States, 2004. — July (vol. 279, no. 27). — P. 28585—28591. — ISSN 0021-9258. — doi:10.1074/jbc.M312913200. — PMID 15100233.
↑ Chai, Weihang; Ford Lance P., Lenertz Lisa, Wright Woodring E., Shay Jerry W. Human Ku70/80 associates physically with telomerase through interaction with hTERT (англ.) // J. Biol. Chem. : journal. — United States, 2002. — December (vol. 277, no. 49). — P. 47242—47247. — ISSN 0021-9258. — doi:10.1074/jbc.M208542200. — PMID 12377759.
↑ Schild-Poulter, C; Pope L., Giffin W., Kochan J C., Ngsee J K., Traykova-Andonova M., Haché R J. The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase (англ.) // J. Biol. Chem. : journal. — United States, 2001. — May (vol. 276, no. 20). — P. 16848—16856. — ISSN 0021-9258. — doi:10.1074/jbc.M100768200. — PMID 11279128.
↑ Ohta, Satoshi; Shiomi Yasushi, Sugimoto Katsunori, Obuse Chikashi, Tsurimoto Toshiki. A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein (англ.) // J. Biol. Chem. : journal. — United States, 2002. — October (vol. 277, no. 43). — P. 40362—40367. — ISSN 0021-9258. — doi:10.1074/jbc.M206194200. — PMID 12171929.
↑ Balajee, A S; Geard C R. Chromatin-bound PCNA complex formation triggered by DNA damage occurs independent of the ATM gene product in human cells (англ.) // Nucleic Acids Res. : journal. — England, 2001. — March (vol. 29, no. 6). — P. 1341—1351. — PMID 11239001.

Литература

Koike M. Dimerization, translocation and localization of Ku70 and Ku80 proteins. (англ.) // J. Radiat. Res. : journal. — 2003. — Vol. 43, no. 3. — P. 223—236. — doi:10.1269/jrr.43.223. — PMID 12518983.
Chen D.J., Park M.S., Campbell E., et al. Assignment of a human DNA double-strand break repair gene (XRCC5) to chromosome 2. (англ.) // Genomics : journal. — Academic Press, 1992. — Vol. 13, no. 4. — P. 1088—1094. — doi:10.1016/0888-7543(92)90023-L. — PMID 1505945.
Wedrychowski A., Henzel W., Huston L., et al. Identification of proteins binding to interferon-inducible transcriptional enhancers in hematopoietic cells. (англ.) // J. Biol. Chem. : journal. — 1992. — Vol. 267, no. 7. — P. 4533—4540. — PMID 1537839.
Jeggo P.A., Hafezparast M., Thompson A.F., et al. Localization of a DNA repair gene (XRCC5) involved in double-strand-break rejoining to human chromosome 2. (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1992. — Vol. 89, no. 14. — P. 6423—6427. — doi:10.1073/pnas.89.14.6423. — PMID 1631138.
Knuth M.W., Gunderson S.I., Thompson N.E., et al. Purification and characterization of proximal sequence element-binding protein 1, a transcription activating protein related to Ku and TREF that binds the proximal sequence element of the human U1 promoter. (англ.) // J. Biol. Chem. : journal. — 1990. — Vol. 265, no. 29. — P. 17911—17920. — PMID 2211668.
Stuiver M.H., Coenjaerts F.E., van der Vliet P.C. The autoantigen Ku is indistinguishable from NF IV, a protein forming multimeric protein-DNA complexes. (англ.) // Journal of Experimental Medicine : journal. — Rockefeller University Press, 1990. — Vol. 172, no. 4. — P. 1049—1054. — doi:10.1084/jem.172.4.1049. — PMID 2212941.
Mimori T., Ohosone Y., Hama N., et al. Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome. (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1990. — Vol. 87, no. 5. — P. 1777—1781. — doi:10.1073/pnas.87.5.1777. — PMID 2308937.
Yaneva M., Wen J., Ayala A., Cook R. cDNA-derived amino acid sequence of the 86-kDa subunit of the Ku antigen. (англ.) // J. Biol. Chem. : journal. — 1989. — Vol. 264, no. 23. — P. 13407—13411. — PMID 2760028.
Genersch E., Eckerskorn C., Lottspeich F., et al. Purification of the sequence-specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen. (англ.) // Embo J. : journal. — 1995. — Vol. 14, no. 4. — P. 791—800. — PMID 7882982.
Tuteja N., Tuteja R., Ochem A., et al. Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen. (англ.) // Embo J. : journal. — 1994. — Vol. 13, no. 20. — P. 4991—5001. — PMID 7957065.
Le Romancer M., Reyl-Desmars F., Cherifi Y., et al. The 86-kDa subunit of autoantigen Ku is a somatostatin receptor regulating protein phosphatase-2A activity. (англ.) // J. Biol. Chem. : journal. — 1994. — Vol. 269, no. 26. — P. 17464—17468. — PMID 8021251.
Cao Q.P., Pitt S., Leszyk J., Baril E.F. DNA-dependent ATPase from HeLa cells is related to human Ku autoantigen. (англ.) // Biochemistry : journal. — 1994. — Vol. 33, no. 28. — P. 8548—8557. — doi:10.1021/bi00194a021. — PMID 8031790.
Taccioli G.E., Gottlieb T.M., Blunt T., et al. Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. (англ.) // Science : journal. — 1994. — Vol. 265, no. 5177. — P. 1442—1445. — doi:10.1126/science.8073286. — PMID 8073286.
Chen D.J., Marrone B.L., Nguyen T., et al. Regional assignment of a human DNA repair gene (XRCC5) to 2q35 by X-ray hybrid mapping. (англ.) // Genomics : journal. — Academic Press, 1994. — Vol. 21, no. 2. — P. 423—427. — doi:10.1006/geno.1994.1287. — PMID 8088837.
Maruyama K., Sugano S. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (англ.) // Gene : journal. — Elsevier, 1994. — Vol. 138, no. 1—2. — P. 171—174. — doi:10.1016/0378-1119(94)90802-8. — PMID 8125298.
Kaczmarski W., Khan S.A. Lupus autoantigen Ku protein binds HIV-1 TAR RNA in vitro. (англ.) // Biochem. Biophys. Res. Commun. : journal. — 1993. — Vol. 196, no. 2. — P. 935—942. — doi:10.1006/bbrc.1993.2339. — PMID 8240370.
Blunt T., Taccioli G.E., Priestley A., et al. A YAC contig encompassing the XRCC5 (Ku80) DNA repair gene and complementation of defective cells by YAC protoplast fusion. (англ.) // Genomics : journal. — Academic Press, 1996. — Vol. 30, no. 2. — P. 320—328. — doi:10.1006/geno.1995.9871. — PMID 8586433.
Warriar N., Pagé N., Govindan M.V. Expression of human glucocorticoid receptor gene and interaction of nuclear proteins with the transcriptional control element. (англ.) // J. Biol. Chem. : journal. — 1996. — Vol. 271, no. 31. — P. 18662—18671. — doi:10.1074/jbc.271.31.18662. — PMID 8702520.
Myung K., He D.M., Lee S.E., Hendrickson E.A. KARP-1: a novel leucine zipper protein expressed from the Ku86 autoantigen locus is implicated in the control of DNA-dependent protein kinase activity. (англ.) // Embo J. : journal. — 1997. — Vol. 16, no. 11. — P. 3172—3184. — doi:10.1093/emboj/16.11.3172. — PMID 9214634.
Jin S., Kharbanda S., Mayer B., et al. Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit. (англ.) // J. Biol. Chem. : journal. — 1997. — Vol. 272, no. 40. — P. 24763—24766. — doi:10.1074/jbc.272.40.24763. — PMID 9312071.

[entrez-1] ¹ ² Entrez Gene: XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa) .

[pmid9501103-2] Boulton S.J., Jackson S.P. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing (англ.) // EMBO J. : journal. — 1998. — March (vol. 17, no. 6). — P. 1819—1828. — doi:10.1093/emboj/17.6.1819. — PMID 9501103. — PMC 1170529.

[autogenerated1-3] Entrez Gene: XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa) . Архивировано 8 марта 2010 года.

[pmid10823961-4] Ko, L; Cardona G R., Chin W W. Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — UNITED STATES, 2000. — May (vol. 97, no. 11). — P. 6212—6217. — ISSN 0027-8424. — PMID 10823961.

[pmid12519782-5] Ko, Lan; Chin William W. Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase (англ.) // J. Biol. Chem. : journal. — United States, 2003. — March (vol. 278, no. 13). — P. 11471—11479. — ISSN 0021-9258. — doi:10.1074/jbc.M209723200. — PMID 12519782.

[pmid9488450-6] ¹ ² Barlev, N A; Poltoratsky V., Owen-Hughes T., Ying C., Liu L., Workman J L., Berger S L. Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex (англ.) // Mol. Cell. Biol. : journal. — UNITED STATES, 1998. — March (vol. 18, no. 3). — P. 1349—1358. — ISSN 0270-7306. — PMID 9488450.

[pmid10446239-7] ¹ ² Gell, D; Jackson S P. Mapping of protein-protein interactions within the DNA-dependent protein kinase complex (англ.) // Nucleic Acids Res. : journal. — ENGLAND, 1999. — September (vol. 27, no. 17). — P. 3494—3502. — PMID 10446239.

[pmid10219089-8] Yang, C R; Yeh S., Leskov K., Odegaard E., Hsu H L., Chang C., Kinsella T J., Chen D J., Boothman D A. Isolation of Ku70-binding proteins (KUBs) (англ.) // Nucleic Acids Res. : journal. — ENGLAND, 1999. — May (vol. 27, no. 10). — P. 2165—2174. — ISSN 0305-1048. — PMID 10219089.

[pmid10207052-9] Singleton, B K; Torres-Arzayus M I., Rottinghaus S T., Taccioli G E., Jeggo P A. The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit (англ.) // Mol. Cell. Biol. : journal. — UNITED STATES, 1999. — May (vol. 19, no. 5). — P. 3267—3277. — ISSN 0270-7306. — PMID 10207052.

[pmid10984620-10] Song, K; Jung D., Jung Y., Lee S G., Lee I. Interaction of human Ku70 with TRF2 (англ.) // FEBS Lett. : journal. — NETHERLANDS, 2000. — September (vol. 481, no. 1). — P. 81—5. — ISSN 0014-5793. — PMID 10984620.

[pmid12177300-11] Karmakar, Parimal; Snowden Carey M., Ramsden Dale A., Bohr Vilhelm A. Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus (англ.) // Nucleic Acids Res. : journal. — England, 2002. — August (vol. 30, no. 16). — P. 3583—3591. — PMID 12177300.

[pmid10880505-12] Li, B; Comai L. Functional interaction between Ku and the werner syndrome protein in DNA end processing (англ.) // J. Biol. Chem. : journal. — UNITED STATES, 2000. — September (vol. 275, no. 37). — P. 28349—28352. — ISSN 0021-9258. — doi:10.1074/jbc.C000289200. — PMID 10880505.

[pmid10673353-13] Adam, L; Bandyopadhyay D., Kumar R. Interferon-alpha signaling promotes nucleus-to-cytoplasmic redistribution of p95Vav, and formation of a multisubunit complex involving Vav, Ku80, and Tyk2 (англ.) // Biochem. Biophys. Res. Commun. : journal. — UNITED STATES, 2000. — January (vol. 267, no. 3). — P. 692—696. — ISSN 0006-291X. — doi:10.1006/bbrc.1999.1978. — PMID 10673353.

[pmid9312071-14] Jin, S; Kharbanda S., Mayer B., Kufe D., Weaver D T. Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit (англ.) // J. Biol. Chem. : journal. — UNITED STATES, 1997. — October (vol. 272, no. 40). — P. 24763—24766. — ISSN 0021-9258. — PMID 9312071.

[pmid12393188-15] ¹ ² ³ Matheos, Diamanto; Ruiz Marcia T., Price Gerald B., Zannis-Hadjopoulos Maria. Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication (англ.) // Biochim. Biophys. Acta : journal. — Netherlands, 2002. — October (vol. 1578, no. 1—3). — P. 59—72. — ISSN 0006-3002. — PMID 12393188.

[pmid15100233-16] O'Connor, Matthew S; Safari Amin, Liu Dan, Qin Jun, Songyang Zhou. The human Rap1 protein complex and modulation of telomere length (англ.) // J. Biol. Chem. : journal. — United States, 2004. — July (vol. 279, no. 27). — P. 28585—28591. — ISSN 0021-9258. — doi:10.1074/jbc.M312913200. — PMID 15100233.

[pmid12377759-17] Chai, Weihang; Ford Lance P., Lenertz Lisa, Wright Woodring E., Shay Jerry W. Human Ku70/80 associates physically with telomerase through interaction with hTERT (англ.) // J. Biol. Chem. : journal. — United States, 2002. — December (vol. 277, no. 49). — P. 47242—47247. — ISSN 0021-9258. — doi:10.1074/jbc.M208542200. — PMID 12377759.

[pmid11279128-18] Schild-Poulter, C; Pope L., Giffin W., Kochan J C., Ngsee J K., Traykova-Andonova M., Haché R J. The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase (англ.) // J. Biol. Chem. : journal. — United States, 2001. — May (vol. 276, no. 20). — P. 16848—16856. — ISSN 0021-9258. — doi:10.1074/jbc.M100768200. — PMID 11279128.

[pmid12171929-19] Ohta, Satoshi; Shiomi Yasushi, Sugimoto Katsunori, Obuse Chikashi, Tsurimoto Toshiki. A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein (англ.) // J. Biol. Chem. : journal. — United States, 2002. — October (vol. 277, no. 43). — P. 40362—40367. — ISSN 0021-9258. — doi:10.1074/jbc.M206194200. — PMID 12171929.

[pmid11239001-20] Balajee, A S; Geard C R. Chromatin-bound PCNA complex formation triggered by DNA damage occurs independent of the ATM gene product in human cells (англ.) // Nucleic Acids Res. : journal. — England, 2001. — March (vol. 29, no. 6). — P. 1341—1351. — PMID 11239001.

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